S. 339: Nancy Gardner Sewell Medicare Multi-Cancer Early Detection Screening Coverage Act

Signed Into LawPublic Law 119-75

Enacted as part of HR7148: Consolidated Appropriations Act, 2026· Feb 3, 2026

Sponsor

Mike Crapo

Mike Crapo

Republican · ID

Bill Progress

IntroducedJan 30
Committee 
Pass Senate 
Pass House 
Signed 
Law 

Latest Action · Jan 30, 2025

1/4

Read twice and Referred to Finance. for review

Medicare should cover blood tests that spot multiple cancers

4 min readLast updated April 28, 2026

Why it matters

Starting in 2028, Medicare could pay for one blood-based screening test that looks for multiple cancers at once. But S. 339 would begin with a hard age cutoff: if you were already 68 on January 1, 2028, Medicare would not pay unless the test later wins a top federal prevention rating.

S. 339 creates a Medicare coverage pathway for multi-cancer early detection tests beginning in 2028. To qualify, a test has to look for multiple cancers across multiple organs, have FDA clearance or approval, and be deemed appropriate for Medicare patients by the Health and Human Services secretary.

The bill is written mainly around blood-based genomic tests that analyze cell-free nucleic acids, though it also allows other biological-sample tests if federal officials decide they produce comparable results. Coverage decisions for new tests would go through Medicare's national coverage determination process.

What does S. 339 do?

1

Medicare starts covering multi-cancer screening in 2028

Beginning in 2028, Medicare could cover qualifying multi-cancer early detection tests for people in Part A or Part B once federal health officials determine the test is appropriate and medically justified for Medicare patients.

2

One test can screen for multiple cancers

The bill covers tests designed to detect multiple cancer types across multiple organs in a single screening, rather than a test aimed at just one cancer.

3

Most qualifying tests will be blood-based

S. 339 is built mainly around genomic blood or blood-product tests that analyze cell-free nucleic acids, but it leaves room for other biological-sample tests if the government decides they deliver comparable results.

4

Repeat testing is limited

Medicare would generally not pay for another covered test if you had one in the previous 11 months.

5

Older beneficiaries are initially excluded

The bill blocks payment in 2028 for anyone who had already reached age 68 by January 1 of that year. The threshold then rises to 69 in 2029, 70 in 2030, and continues increasing by one year annually.

6

A top prevention rating wipes out the limits

If the United States Preventive Services Task Force gives a test an A or B grade, the age cutoff and 11-month limit no longer apply to that test.

7

Current cancer screenings stay in place

The bill says Medicare coverage for mammograms and other existing screenings for breast, cervical, colorectal, lung, and prostate cancer cannot be reduced just because this new category is added.

Who benefits from S. 339?

Medicare patients who want earlier warning signs

If you are eligible, S. 339 could give you Medicare coverage for a single screening test aimed at detecting multiple cancers before symptoms appear.

People approaching Medicare age in coming years

Because the age threshold rises by one year every year after 2028, younger Medicare beneficiaries would gradually gain a clearer path to coverage.

Doctors adding a new screening option

Clinicians would have another Medicare-paid screening tool to discuss with patients, while still keeping standard cancer screenings in place.

Companies making qualifying cancer detection tests

Manufacturers whose tests clear federal review and meet Medicare's standards would get a defined national coverage pathway for this new category of screening.

Who is affected by S. 339?

Beneficiaries already 68 or older in 2028

If you had turned 68 by January 1, 2028, Medicare would not pay for the new screening that year unless the test later receives an A or B recommendation from the federal preventive services panel.

Patients seeking frequent repeat screening

Anyone wanting another covered test within 11 months would generally have to pay out of pocket unless the test has that A or B recommendation.

Test makers whose products do not qualify

Tests that are not cleared or approved by FDA, or that Medicare does not find appropriate for detecting multiple cancers across multiple organs, would not be covered.

Federal health officials running coverage reviews

Health and Human Services would have to evaluate new tests through Medicare's national coverage determination process and decide whether non-blood tests are comparable enough to qualify.

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On the Record

What Congress Is Saying

S. 339 hasn't been debated on the floor yet.

This section updates when a legislator speaks about it on the floor or in committee.

S339 Legislative Journey

1 actions

Committee Action

Jan 30, 2025

Read twice and referred to the Committee on Finance.

About the Sponsor

Mike Crapo

Mike Crapo

Republican, ID · 33 years in Congress

Committees: Finance, Joint Committee on Taxation, Banking, Housing, and Urban Affairs

View full profile →

Cosponsors at time of passage (68)

This bill has 68 cosponsors: 35 Democrats, 32 Republicans, 1 Independent, reflecting bipartisan support. Cosponsors represent 44 states: Alaska, Alabama, Arkansas, and 41 more.

35Democrats32Republicans1Independent·44 statesBipartisan

Committee Sponsors

S. 339 Quick Facts

Cosponsors
68
Michael Bennet
Tim Scott
Ron Wyden
James Lankford
Mike Rounds
+63 more
Committee
Finance
Chamber
Senate
Policy
Health
Introduced
Jan 30, 2025

Read twice and Referred to Finance. for review

Jan 30, 2025

Official Sources

S. 339 on Congress.gov

Official Congress.gov page for the Nancy Gardner Sewell Medicare Multi-Cancer Early Detection Screening Coverage Act.

CMS National Coverage Determination Process

The bill requires the Secretary to use Medicare's national coverage determination process when deciding coverage for new multi-cancer early detection tests.

CMS Medicare Preventive Services

Official Medicare information on preventive screening coverage, relevant to how this new screening category would fit within existing Medicare benefits.

FDA Premarket Approval (PMA)

Official FDA page covering one of the approval pathways specifically referenced in the bill text for qualifying cancer detection tests.

Medicare Coverage of Colorectal Cancer Screening

The bill says adding multi-cancer early detection tests cannot reduce coverage for existing screenings such as colorectal cancer screening.

About Legisletter

Legisletter is the advocacy platform that tracks every bill from introduction to Public Law — and connects the constituents affected by a bill to the legislators who vote on it.

S. 339 Common Questions

When would Medicare start covering these multi-cancer blood tests?

If S. 339 passes, Medicare coverage would begin for qualifying tests on or after January 1, 2028.

Would Medicare cover a blood test that checks for several cancers at once?

Yes, if the test meets the bill's standards. It must detect multiple cancers across multiple organs, have FDA clearance or approval, and be approved by Medicare as appropriate for beneficiaries.

How often would Medicare pay for the test?

Generally, once every 11 months. If you had one of these covered tests during the previous 11 months, Medicare would not pay for another one.

Would people 68 and older be excluded in 2028?

Yes, at first. S. 339 says Medicare would not pay in 2028 if you had already turned 68 by January 1 of that year.

Does that age limit stay at 68 forever?

No. The cutoff rises by 1 year each year after 2028—69 in 2029, 70 in 2030, 71 in 2031, and so on.

What happens if the test gets a top federal prevention rating?

If the United States Preventive Services Task Force gives a test a grade of A or B, the bill says the age cap and 11-month limit would no longer apply to that test.

Would this replace mammograms or colon cancer screening?

No. S. 339 says Medicare coverage for existing screenings like breast, cervical, colorectal, lung, and prostate cancer tests would stay in place.

Does S. 339 set a specific price Medicare would pay?

Not a new dollar amount. Before 2031, payment would track the rate for a covered stool DNA screening test. After that, Medicare would use the lower of that benchmark or its regular lab-test pricing formula.

Based on S. 339 bill text

S. 339 Bill Text

To amend title XVIII of the Social Security Act to provide for Medicare coverage of multi-cancer early detection screening tests.

Source: U.S. Government Publishing Office

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