The Committee on Energy and Natural Resources handles matters related to energy development, conservation, regulation, nuclear energy, national parks, public lands, and natural resource management. It oversees the Department of Energy and the Department of the Interior.

The Committee on Finance holds broad jurisdiction over taxation and revenue measures, the nation's debt, customs, international trade, and key social programs. It oversees Social Security, Medicare, Medicaid, and unemployment benefits, shaping fiscal policy and health legislation.

The Committee on Health, Education, Labor, and Pensions (HELP) oversees matters relating to public health, education, labor standards, employment, and retirement security. It addresses issues ranging from biomedical research and food/drug safety to K-12 education, workplace safety, and private pension plans.

The Committee on Veterans' Affairs handles legislation related to veterans' benefits, healthcare, housing, employment, and memorials. It provides oversight for the Department of Veterans Affairs (VA) and addresses issues affecting former service members.