The Committee on Commerce, Science, and Transportation addresses a wide range of issues including interstate commerce, transportation systems, science and technology policy, space exploration, and consumer protection. It oversees agencies like the Department of Transportation, NASA, the FCC, and the FTC.

The Committee on Energy and Natural Resources handles matters related to energy development, conservation, regulation, nuclear energy, national parks, public lands, and natural resource management. It oversees the Department of Energy and the Department of the Interior.

The Committee on Health, Education, Labor, and Pensions (HELP) oversees matters relating to public health, education, labor standards, employment, and retirement security. It addresses issues ranging from biomedical research and food/drug safety to K-12 education, workplace safety, and private pension plans.

The Committee on Small Business and Entrepreneurship focuses on issues affecting small businesses, including access to capital, federal procurement opportunities, and regulatory burdens. It provides oversight of the Small Business Administration (SBA) and develops legislation aimed at fostering entrepreneurship.