The Committee on Armed Services exercises legislative oversight for the nation's military, including the Department of Defense, military research and development, nuclear energy activities, and benefits for members of the armed forces. It also handles the confirmation of presidential nominees for senior defense and military positions.

The Committee on Commerce, Science, and Transportation addresses a wide range of issues including interstate commerce, transportation systems, science and technology policy, space exploration, and consumer protection. It oversees agencies like the Department of Transportation, NASA, the FCC, and the FTC.

The Committee on Environment and Public Works deals with legislation concerning environmental protection, infrastructure projects like highways and water systems, and disaster response. Its jurisdiction includes oversight of the Environmental Protection Agency and the Army Corps of Engineers.

The Select Committee on Intelligence provides vigilant legislative oversight of the United States Intelligence Community, ensuring activities conform to the Constitution and laws. It reviews intelligence budgets, programs, and operations, and prepares legislation authorizing appropriations for intelligence agencies.

The Committee on Rules and Administration oversees the rules and procedures of the Senate, federal election laws, campaign finance, presidential succession, and the administration of Senate buildings. It also manages entities like the Government Publishing Office and the Library of Congress.

Also known as the Helsinki Commission, this independent agency monitors compliance with the Helsinki Accords and advances human rights, democracy, and security in the OSCE region. It comprises members from the House, Senate, and the Executive Branch, engaging in public diplomacy and policy recommendations.