The Committee on Foreign Relations leads Senate consideration of U.S. foreign policy, including treaties, diplomatic nominations, foreign aid, and arms control. It shapes legislation concerning international relations and provides oversight of the State Department and other foreign affairs agencies.

The Committee on Health, Education, Labor, and Pensions (HELP) oversees matters relating to public health, education, labor standards, employment, and retirement security. It addresses issues ranging from biomedical research and food/drug safety to K-12 education, workplace safety, and private pension plans.

The Committee on Homeland Security and Governmental Affairs provides oversight of homeland security operations and the efficiency and management of the federal government. Its jurisdiction includes counterterrorism, cybersecurity, border security, emergency management, and governmental affairs, including the Postal Service and the Census Bureau.

The Committee on Small Business and Entrepreneurship focuses on issues affecting small businesses, including access to capital, federal procurement opportunities, and regulatory burdens. It provides oversight of the Small Business Administration (SBA) and develops legislation aimed at fostering entrepreneurship.