The Committee on Energy and Natural Resources handles matters related to energy development, conservation, regulation, nuclear energy, national parks, public lands, and natural resource management. It oversees the Department of Energy and the Department of the Interior.

The Select Committee on Ethics administers and enforces the Senate's Code of Official Conduct, investigating allegations of improper conduct by members, officers, or employees. It issues advisory opinions, provides ethics training, and oversees financial disclosure requirements and regulations on gifts and franking privileges.

The Committee on Foreign Relations leads Senate consideration of U.S. foreign policy, including treaties, diplomatic nominations, foreign aid, and arms control. It shapes legislation concerning international relations and provides oversight of the State Department and other foreign affairs agencies.

The Select Committee on Intelligence provides vigilant legislative oversight of the United States Intelligence Community, ensuring activities conform to the Constitution and laws. It reviews intelligence budgets, programs, and operations, and prepares legislation authorizing appropriations for intelligence agencies.

The Committee on Small Business and Entrepreneurship focuses on issues affecting small businesses, including access to capital, federal procurement opportunities, and regulatory burdens. It provides oversight of the Small Business Administration (SBA) and develops legislation aimed at fostering entrepreneurship.

The United States Senate Caucus on International Narcotics Control oversees and promotes international cooperation against drug trafficking and abuse. It monitors U.S. counternarcotics policies and programs abroad, working with foreign governments and international bodies.