The Committee on Appropriations holds the power of the purse, responsible for writing legislation that allocates federal funds to numerous government agencies, departments, and organizations. Its twelve subcommittees determine spending levels for discretionary programs across the government, after reviewing presidential budget requests and holding hearings.

The Committee on Armed Services exercises legislative oversight for the nation's military, including the Department of Defense, military research and development, nuclear energy activities, and benefits for members of the armed forces. It also handles the confirmation of presidential nominees for senior defense and military positions.

The Committee on Banking, Housing, and Urban Affairs oversees legislation related to banks, financial institutions, housing, urban development, and economic policy. Its jurisdiction includes monetary policy, financial stability, consumer protection in financial services, securities markets, and international finance.

The Committee on Indian Affairs studies matters pertaining to American Indian, Native Hawaiian, and Alaska Native peoples. It handles legislation related to tribes, land management, health, education, and economic development for Native populations.

The Select Committee on Intelligence provides vigilant legislative oversight of the United States Intelligence Community, ensuring activities conform to the Constitution and laws. It reviews intelligence budgets, programs, and operations, and prepares legislation authorizing appropriations for intelligence agencies.