The Committee on Appropriations holds the power of the purse, responsible for writing legislation that allocates federal funds to numerous government agencies, departments, and organizations. Its twelve subcommittees determine spending levels for discretionary programs across the government, after reviewing presidential budget requests and holding hearings.

The Select Committee on Ethics administers and enforces the Senate's Code of Official Conduct, investigating allegations of improper conduct by members, officers, or employees. It issues advisory opinions, provides ethics training, and oversees financial disclosure requirements and regulations on gifts and franking privileges.

The Committee on Foreign Relations leads Senate consideration of U.S. foreign policy, including treaties, diplomatic nominations, foreign aid, and arms control. It shapes legislation concerning international relations and provides oversight of the State Department and other foreign affairs agencies.

The Committee on the Judiciary conducts oversight of the Department of Justice and considers nominations for federal judgeships, including the Supreme Court. Its legislative jurisdiction covers constitutional amendments, federal criminal law, immigration, antitrust, patents, and civil liberties.

The Committee on Small Business and Entrepreneurship focuses on issues affecting small businesses, including access to capital, federal procurement opportunities, and regulatory burdens. It provides oversight of the Small Business Administration (SBA) and develops legislation aimed at fostering entrepreneurship.